Gorgon
Member
GothPunk said:What a great thread!
I should introduce mahself. I graduated in Cell and Molecular Biology two and a half years ago, and went straight into a PhD in Molecular Medicine. I work in neuropsychiatric genetics, performing a functional follow-up of a gene implicated in autism via a genome wide association study. Everything in our group is exome sequencing this and next-gen sequencing that, so I feel lucky as a functional genomics biologist there is a lot of work up and coming for people will such skills (as it's not enough to just implicate mutations in disease, we need to know the function!). My work is mostly just research as part of a consortia, but there are people in my group who meet with patients and take DNA samples from them, so hopefully one day those people or their relatives will see treatments come about due to their participation in genetic studies.
I think the most interesting thing I have learnt recently was at the most recent European Society for Human Genetics meeting. There was a seminar about intellectual disability where they were discussing how, using next-gen sequencing, many of the mutations that they have found to be risk factors (or even causative) were not in 'neuron specific' genes, but in general 'housekeeping genes', cell adhesion molecules etc. This was interesting for me in terms of my research, but I also think it demonstrates the power that next generation sequencing technology has in enabling us to find genes implicated in a disorder that people had ignored for one reason or another. It goes to show you that the 'hypothesis free' approach of genome wide association studies and whole genome sequencing isn't all bad. ^^
Were they discussing fMRI? Some of the clinical psychologists in my group use that with patients, I've seen some of their raw data at their presentations, they really are fascinating to look at - like a heat map of brain activity in 3D. Mammalian brains are just so cool!
Thanks for sharing, man. Welcome to the thread.
PantherLotus said:You guys see the tevatron findings weren't able to be duplicated? :|
Yep.