My favorite show of the last few years has been
Severance
A great mix of unique ideas which give place to interesting themes, great characters and performances and an overall weird and mysterious tone which I love.
The basic premise is about a dude who works at a company which makes you undergo a procedure in which while you are at work you don't remember anything about your life outside of it, and while you aren't working you don't remember anything you do at work.
That said it does have "mystery box" elements to it, and with only 1 season out so far there's still plenty of time to disappoint. Though I would argue Season 1 would even work well as a standalone story even if it doesn't explain everything.
On the animated front I really liked
Scavengers Reign
It's about a group of people trying to survive (and possibly escape) from an alien planet on which they crashed landed on.
While the characters are compelling what I really enjoyed was the world itself. The visual style is great, it often almost looks like a Moebius work in motion, and the show focuses a lot on showcasing unique environments with weird, often unsettling, flora and fauna and the way they interact with each other (and the humans)
In a genre that's usually dominated by grey spaceship corridors or advanced alien tech, I really liked the approach of making alien biology the focus