In a perfect world, Indiana Jones would always be relevant, being the quintessence of a certain type of story that it is. Indiana Jones should be remembered through the centuries like King Arthur or the paladin Roland. He's the archetype of the treasure hunter. He's cool. He's the ladies' man. He raids ancient tombs. He finds lost cities. He kicks Nazi ass. He uses a goddamn whip. If Indy isn't the stuff of legend, I don't know who is.
Harsh truth is, in this fast world of here today, come tomorrow, he isn't that commercially relevant anymore. But a good Indiana Jones game has the potential of being better than a similar good game that doesn't have Indiana Jones in it.