I think that's the dilemma that has kept Strider from returning in 3d form for many years.
It's hard to make that concept work today.
Focusing on combos and technique wouldn't suit; the original put a lot of emphasis on platforming, jumping, climbing with a single attack move and something like that would be perceived as way too shallow for a retail game.
Anyway, this is certainly going to be 2.5D. I mean, XBLA already gives it away.
Not a straight remake of the arcade since the logo is different and the artwork is not from any stage of the original. Plus, Strider arcade is a game you can complete in like 10 minutes and that's just not acceptable today.
NES version was somewhat meatier in structure, but also far from the original in many ways.
I hope it retains Strider arcade structure and artstyle with tons more content and setpieces, but i'm sure this will turn from most wanted to disappointmenton in a matter of seconds.