The REAL problem is that black people ain't as cool as white/Italians perception wise. When you think white/Italian criminals; there is an aura of yeah.. the cool factor. Black people; you'd associate with slums and ghettos, pimps, druggies and all the really negative associations (WHICH they've been dealt an unfair hand with). Mention Harlem and nothing really good comes out in relationship to the area. Racial stereotypes are deeply ingrained IMO. White america will find it hard to deal with the theme. I personally can't watch black porn. GTA SA sounds like something I won't be able to get into. (But then I wasn't too impressed with GTA to go run out and buy VC).
I think once word gets out about the setting. This game won't sell that well. (DID DEF JAM sell well?) Fact that Manhunt sold like crap is also indicative that maybe the lustre on violent games is wearing out.