Why? How would it change the game? Would making Samus into a guy do anything for Metroid? Link is male, he's been male since time immemorial. He's always reborn a male, just like Zelda is reborn a female. It's also why Ganondorf is always a male Gerudo. No gender swapping for characters that have been established for almost 25+ years please. That's just who the characters are.
I'm in favor of more woman representation in games, having more female protagonists, but I'm vehemently dead set against changing such a character.
Back on topic, I'd want the same characters, but wouldn't mind a bigger jump into 'future' sort of like spirit tracks, where more technology is introduced, just to see. Or a game that takes place in the time Link was in the temple of time and how Zelda became Sheik and fought back against Ganondorf. Maybe have it play like Assassins Creed, set in open world Hyrule. Zelda can switch from princess to Sheik and has different attributes such as speed and melee combat as Sheik and magic/arrows as Zelda.
I want another game, that also takes Link and Zelda further than just children or teens. Maybe the hero of time was delayed until he's an older man, and Ganondorf is a teen villain.