It's undoable to make it look good in all areas. I personally turn off AO in some areas. The outside of Aldia's Manor looks hideous with the kind of AO I've configured. Foggy areas are not friendly for the AO. Could be solved if Boris V. put more work into it, but he won't. Also, don't try playing with this (and most) ENB's in the Shaded Woods. 
Same goes for the bloom. There are reasons why I never released this ENB. You're all better off choosing GEM-ENB, Wickfut's, Confidence Man's or Kalicola's.
Sharpening and bloom are resolution-sensitive, and I have it all configured to look good (to me) at 6-7K. It's NOT configured for 1080p. Ramp down the sharpening in SweetFX and the bloom scale in enbbloom.fx or via the GUI if you're uncomfortable editing shaders.