Did you know where the characters were going when they got lost in an alien beehive and started smoking weed in their spacesuits to calm their nerves?
But in all realness there were like two locations in the movie so it wasn't hard to be situated geographically. The bigger issue was being lost in what the hell was going on and why anything was happening. Are we supposed to be afraid of the alien snakes, or the person zombie, or the squid, or the engineer, or David, or random old man guy pierce...it had no focus and the lack of any reasonable character motivations and terrible tension building just made it feel like sludge.
I don't even think the cinematography was that good either. It was slickly polished in Ridley's current very commerical looking way, and generally aesthetically pleasing, but it didn't help tell the story particularly well, and I certainly wasn't wowed enough by it to forget about the rest of the movie.