If you picked up LoL, you can pick up this game. There are a few more systems going on (Stats are a bit more complex, Day/Night System which primarily effects vision, Deny system which is just last hitting your own creeps, the jungle is different, wards work a bit differently, but on the other end there is no masteries, summoner spells, runes, scaling spells, or cooldown reduction), but after a few hours you will get the hang of the bulk of it, and it will then turn into a game of learning what 60+ characters and 100+ items do, but LoL is similar in that regard.