Grab ffmpeg from
https://www.ffmpeg.org/download.html
It's a command line tool which means you will have to type things with your keyboard instead of clicking on buttons.
The most trivial operation would be converting gifs:
ffmpeg -i your_gif.gif -c:v libvpx -crf 12 -b:v 500K output.webm
-crf values can go from 4 to 63. Lower values mean better quality.
-b:v is the maximum allowed bitrate. Higher means better quality.
To convert a part of a video file:
ffmpeg -i your_video.mkv -ss 00:00:10.000 -to 00:00:20.000 -c:v libvpx -crf 4 -b:v 1500K -vf scale=640:-1 -an output.webm
-ss is the start position in number of seconds, or in hh:mm:ss[.xxx] format. You can get it using your video player (Ctrl-G in MPC-HC).
-to is the end position.
-vf scale=640:-1 sets the width to 640px. The height will be calculated automatically according to the aspect ratio of the input.
-an disables audio. 4chan will reject your files if they contain audio streams.
Another encoding guide:
https://trac.ffmpeg.org/wiki/vpxEncodingGuide
ffmpeg documentation:
https://www.ffmpeg.org/ffmpeg.html