This is my nightstand setup.
Taurus Judge. This weapon is complete shit unless you understand the exact ammo to use. There are only about 3 ammo types that I would recommend but those are absolutely devastating. It takes the weapon from below average to unparalleled versatility and power.
Of course, most everyone knows it shoots shotgun shells.
For the first two shots, I use buckshot from Federal from the Judge. It's essentially like getting hit with four .380 rounds every trigger pull and the spread is very manageable. No more than 5 inches at house defense ranges.
Penetration is excellent.
Then, to finish out the cylinder, I use Lehigh's specialized bullet for the firearm that takes advantage of the extra-long cylinder.
This is what it looks like on the left compared to a normal .45 on the right. As you can see on the far left, the expansion is insane.
And this is the same bullet above but against the ballistic human gel that the FBI uses.
I can also do a cylinder dump in about 1.4 seconds. So at close range, that means you're getting hit with 12 projectiles but only 5 trigger pulls. Mash potatoes internals.