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Harvard crams 700TB of data into a single gram of DNA

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Just think... I wiped up around 3,500TB of of potential data onto a tissue and threw it in the trash this morning. That would contain, like all of Wikipedia and the library of congress several times over. The entirety of human knowledge!
 

Lesath

Member
A gram of DNA seems like a hell of a lot of DNA.

What does a gram of DNA even look like? If somebody could answer this question without porn, it would be appreciated.

Good question; I wonder that myself, though I suppose it does depend on how tightly packed it all is.

https://flic.kr/p/8j9GLz

So taking the leftmost image and using that as a reference, if 10 ug of DNA occupies ~1 uL of space, then 1 g can occupy...~100 mL?
 

hitme

Member
Genome_Soldiers.jpg


Soon.
 

Not

Banned
Just think... I wiped up around 3,500TB of of potential data onto a tissue and threw it in the trash this morning. That would contain, like all of Wikipedia and the library of congress several times over. The entirety of human knowledge!

Why, you could make a whole human with that kind of data
 

Kieli

Member
I'm not a biologist so can someone explain why DNA is incredibly stable that it could last hundereds of years in a garage, according to the article? Something to do with the strong hydrogen bonds?

Also, how exactly would the DNA interact with electrical equipment to synthesise and decode the DNA?

I actually find this really cool, but what's next? Biological logic gates? lol

DNA is double stranded. Each strand is bound to the other by hydrogen bonds. Hydrogen bonds are fairly weak. They can be broken by heat.

Each strand, however, is stabilized by phosphodiester bonds (essentially, a type of covalent bond where one phosphorus atom is bound to two oxygens). The bonds link the nucleotides (building blocks of DNA) together in a fairly stable manner. As well, the sugars that make up the nucleotides (nucleotides are composed of 3 parts: sugar, phosphate, and nitrogenous bases) lack an oxgen at the 2' (pronounced 2-prime) position. This prevents auto-cleavage (which is incidentally why RNA is not very stable) by a process that involves organic chemistry and nucleophiles and stuff. :p

As a result, the only real ways to degrade DNA would be to use enyzmes (like nucleases) to cut the bonds or subject them to mutagens (things that promote mutation of DNA).
 

Rush_Khan

Member
DNA is double stranded. Each strand is bound to the other by hydrogen bonds. Hydrogen bonds are fairly weak. They can be broken by heat.

Each strand, however, is stabilized by phosphodiester bonds (essentially, a type of covalent bond where one phosphorus atom is bound to two oxygens). The bonds link the nucleotides (building blocks of DNA) together in a fairly stable manner. As well, the sugars that make up the nucleotides (nucleotides are composed of 3 parts: sugar, phosphate, and nitrogenous bases) lack an oxgen at the 2' (pronounced 2-prime) position. This prevents auto-cleavage (which is incidentally why RNA is not very stable) by a process that involves organic chemistry and nucleophiles and stuff. :p

As a result, the only real ways to degrade DNA would be to use enyzmes (like nucleases) to cut the bonds or subject them to mutagens (things that promote mutation of DNA).

Thanks! So would the process of destroying the DNA strands of the storage device (i.e. deleting the data) be done with enzymes? I can't see any other way unless they plan on turning hard drives into carcinogens by using mutagens (lol) so it seems sort of... impractical. But maybe they just point to the storage space as no longer being used with pointers, just like a normal hard drive.
 

Kieli

Member
Thanks! So would the process of destroying the DNA strands of the storage device (i.e. deleting the data) be done with enzymes? I can't see any other way unless they plan on turning hard drives into carcinogens by using mutagens (lol) so it seems sort of... impractical. But maybe they just point to the storage space as no longer being used with pointers, just like a normal hard drive.

If you wanted to delete DNA data, you can definitely use enzymes like nucleases. Nucleases are not very specific, so they'll cut everywhere and essentially break down your entire hard drive.

There are other enzymes that cut at very specific places (e.g. restriction endonucleases). I imagine these will be a lot more useful.
 

Ether_Snake

安安安安安安安安安安安安安安安
So the NSA is stupid for spending so much money in their giant data centers.

Also; how cool would it be if some alien civilization had secretly coded the secrets of the universe in our DNA! Page Giorgio A. Tsoukalos!
 

squidyj

Member
I don't know anything about this technology.... would it be possible to rewrite data with this? what's the theoretical maximum speed of reading and writing this information? I realize now it's quite slow and only suitable for archival purposes but if we assume the technology advances, how far can it go?
 
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