Most definitely. Shinjuku is our base of operations, but we are 10 minutes walking distance from a very large subway station. We have plans almost every day, with a few lazy rest days.
Yeah I wish I had that kind of lax schedule when I went. I tried to cram way too much in 5 days and was exhausted by the end. It does help if your accommodations is close to the train so you can rest midday.