A bit tougher around large mobs, yes.
I'm shying away from crafting skills, personally, and focusing more on utility skills like stealth and persuasion. The game's still easy, but it feels a bit ore balanced when you rely on drops and shops for all your equipment. There's still challenge to be had in Reckoning, but the player sort of has to gimp themselves to get to it. I'm okay with that, but I understand the complaints. Some of my all time favorite games have been a totally unbalanced cakewalk (read: Okami). For those of us who played Skyrim, this unbalance caused by crafting skills should come as no surprise. I don't remember the last RPG I played where passive skills like that were useful and balanced. Seems crafting could be easily fixed by making powerful ingredients extremely rare. Would be easily patched, I think.
So far I've only died once - to one of those electricity traps in Waterhall Down, in the quest where you help Brother Egan. It was my first time through. After getting hit by one I immediately rolled onto another and died. =)