Stewie: ::in a bath of blood:: This is delightful! It's like someone stabbed Mr. Bubbles!
Doctor: Well, Rudolph, we finally figured out what makes your nose red.
Rudolph the Red Nosed Reindeer: Is it pixy dust or Leprechaun tails?
Doctor: No, it's a tumor.
Rudolph: You mean like a magical Christmas tumor?
Doctor: No, a malignant tumor the base of which is lodged deep within your brain.
Rudolph: Oh...like a happy special-
Doctor: You're going to die.
Lois: Peter, what did you promise me last night?
Peter: That I wouldn't drink at the stag party.
Lois: And what did you do?
Peter: Drank at the stag pa -... Whoa! I almost walked right into that one.
Stewie: No sprinkles. For every sprinkle I find, I shall KILL YOU.
Peter: Gays don't vomit. They're a very clean people. And they've been that way ever since they came over to this country from France.
Quagmire: Hello there, cutie. How old are you?
Girl: Sixteen.
Quagmire: Eighteen? You're first.
Girl: MOM!
Quagmire: I like where this is going!
Futurama:
Fry: So you're saying these aren't the decaying ruins of New York in the year 4000?
Professor: You wish. You're in Los Angeles.
Fry: But there was this gang of ten-year-olds with guns.
Leela: Exactly. You're in L.A.
Fry: But everyone is driving around in cars shooting at each other.
Bender: That's L.A. for you.
Fry: But the air is green and there's no sign of civilization whatsoever.
Bender: He just won't stop with the social commentary.
Fry: And the people are all phonies. No one reads. Everything has cilantro on it...
Leela: I... have to tell... must... important... something...
Fry: Whoa, whoa, whoa, slow down. You're going a mile a minute.
Leela: It does seem like Jamaica would be able to field a strong limbo team without you.
Amy: Yeah! Isn't that basically all Jamaicans do?
Hermes: Jamaicans have other interests! Which is why the limbo team got detained at the airport.
Robot Devil: Your lyrics lack subtlety. You can't just have your characters announce how they feel! That makes me feel angry!
Fry: Now he's trapped in a book I wrote, a crummy world of spelling errors and plot holes.
Giant brain: The big brain am winning again! I am the GREETEST! Now I am leaving Earth for NO RAISIN!