An F-Zero made by the disbanded SCE Studio Liverpool/Wipeout team would be something I'd buy a Wii U for.
But Nintendo...
I wouldn't. F-Zero isn't WipEout, they have a totally different focus on handling, design and mechanics. Pretty much all they share in common is their basic genre (racing) and a superficial setting/theme (future) but even those are totally different when you look deeper.
I'm sure the corpse of Psygnosis could make a great Tube Sliders 2 or something though.
A stream of games will sell systems in the long run.
How'd that work out for Xbox 360?
That´s one series against multiple back in the day.
Hardly. Even on it's deathbed Wii sold casual and crossover games pretty damn well in 2012:
010 Dragon Quest X: Mezameshi Itsusu no Shuzoku Online (633,827)
011 Mario Party 9 (622,266)
020 Wii Sports Resort (351,688) 3,084,343
030 Taiko Drum Master Wii: Chougoukaban (308,684)
037 Wii Party (237,243) 2,361,016
039 Mario Lart Wii (232,483) 3,612,831
043 Just Dance Wii (226,014) 653,888
044 Kirby's Dream Collection: Special Edition (225,772)
046 Just Dance Wii 2 (223,628)
055 Kirby's Return to Dream Land (197,036) 695,464
056 Taiko Drum Master Wii: Ketteiban (188,939) 320,770
064 Go Vacation (167,902) 348,704
076 New Super Mario Bros. Wii (148,957) 4,518,492
088 Mario & Sonic at the London 2012 Olympic Games (115,748) 217,264
093 Fortune Street (109,547) 199,092
097 PokéPark 2: Wonders Beyond (106,914) 318,523
And honestly, Wii U's not exactly doing terrible in that regard either for several weeks out:
018 New Super Mario Bros. U (381,315)
050 Nintendo Land (214,374)
The notion that this audience has rejected consoles in Japan is a complete fabrication. Wii Fit U might not reach the dizzying heights of Wii Fit/Plus, but it's still probably going to outsell every PS3, PSP or Vita game released this year in Japan.