Tonight's game was Yokohama, freshly delivered KS funded "goodness" from TMG.
Mixes things from Istanbul, Guilds of London, etc, with more engine building, and kitchen sink victory point generation. 4 player game, all new players, took ~3 hours, and most of us had switched off at hour 2, I think. I ended up winning by a good margin, didn't see it coming, as I was repeatedly blocked throughout the game.
It'll go faster with more familiarity of the tiles & problem space, but fundamentally, because of the movement mechanism, you can't plan too far ahead - you will get messed up by other players' turns. So you end up sometimes doing a lot of thinking just as your turn starts because the board has changed so much.
Meh.
I'd play again, but wouldn't suggest it.