Villeneuve is definitely a great director - I really enjoyed Prisoners ( which was one of my favorite films of 2013 ), and Enemy wasn't bad either.
But I am having troubles with the concept. Blade Runner isn't a movie that should ever get a sequel. It just shouldn't. And it definitely shouldn't be a continuation of Deckard's story - it is perfect as it is, with an ambiguous ending and an air of mystery. Another story within the universe of Blade Runner? Sure, why not. But I am not excited to see the retirement-days of Deckard.
I might be a bit biased, so take this as you see fit ( see my username and avatar ;o ). I am very, very skeptical about the relevance of this sequel. We'll see how it turns out.