RE7 has said the game will have more personalized enemies, and it certainly seems to be based around the Baker Plantation, who cut off communication with the world years ago (I theorized this months ago, but it was confirmed in the newest press release). I think they went into hiding from Umbrella, as they seem to be conducting some type of B.O.W. research, and it's my guess why they've been abducting people. The BSAA and other people haven't looked into it since it's just 'local ghost stories' going on, but the Baker family and residents of it have been brewing a nightmare that is about to lead into an outbreak with a previously unknown virus-strain with different effects than we've seen, which has been confused and associated with ghosts. This is also benefited from the Beginning Hour Teaser demo, where there's a picture of an Umbrella Helicoptor, and someone has written in paranoia, "are they watching from above?". I think the plantation has been doing their own biological research for some reason, and gone into hiding so Umbrella won't take them out or steal their research (as Umbrella is known to do in the series, as they have done and backstabbed various people they worked with, from George Trevor, to William Birkin, etc.), but due to isolation don't realize that Umbrella is dead.
I also think that one of the monsters, likely the Baker's daughter, is a B.O.W. and is after vengeance (which ties into the Aunt Rhody song they chose for the trailer, about being raised in a deep dark hole, a prisoner with no parole, and they took her soul.)..