To be honest, not well. I've been playing guitar for 15 years and Rocksmith has been one long, counter-intuitive struggle for me. Even after inverting the way the strings are displayed along the bottom, I'm still finding it awkward - the fret you're supposed to be at needs to be displayed prominently at all times, yet as the screen moves itself up and down the neck I often find myself scrambling to align myself in time. Each string being assigned a colour rather than their note was confusing at first, but I did manage to get used to it. Chord boxes are another matter though, as the way they're displayed really seems to confuse the hell out of me. Which brings me to possibly my biggest gripe: the menus and looking up chords. I would greatly prefer to know what chords I'm supposed to be hitting before I have to play the song, and to do so you have to; go back to the main menu > go to techniques > go to chord book > scroll through the entire list of songs to find the one you want > select a chord > wait 20 seconds for the game to load a little interactive 'game' where you strum the chord a couple of times > more loading as the game goes back to the main menu. You have to repeat the entire process for every chord you want to look up. Maddening. For me personally, I find it easier to learn songs by sight reading from a tab or youtube video than I have with Rocksmith. I'm sure it's great for people who haven't been playing long/at all, or those who aren't so set in their ways, but it would have been nice to see them cater at least a bit to experienced players. Hell, I would love the option to have a rolling tab of the arrangement at the bottom of the screen as you play, would make things so much easier for me.