Rosie O'Donnell after a year of Mounjaro (weight loss drug like Ozempic)

Brigandier said:
The makers of these drugs literally say "increase dosage if desired affects are not achieved" and when someone loses 10lbs+ in a month they increase the dose even though they've lost weight.... ££$$€€
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They say this kind of shit? That shouldnt even be allowed.

When it comes to meds there's always doctors/pharmacists recommended daily usage and you arent supposed to go over it. Even for OTC stuff you can grab at the drug store yourself has directions for safe usage. Nobody ever goes hog wild saying just keep popping pills or slathering on ointment if you feel like it.

Crazy shit.
 
StreetsofBeige said:
They say this kind of shit? That shouldnt even be allowed.

When it comes to meds there's always doctors/pharmacists recommended daily usage and you arent supposed to go over it. Even for OTC stuff you can grab at the drug store yourself has directions for safe usage. Nobody ever goes hog wild saying just keep popping pills or slathering on ointment if you feel like it.

Crazy shit.
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At the end of each month you can increase dosage by 2.5mg to a max of 15mg but you only need to increase if you really have to, I'm on 5mg now and increasing to 7.5mg next month and I expect that to work soundly and if so I can stay on that dosage if I'm happy.

But Drs and patients are just increasing each month "because fuck it"
 
What happened to the tried and true ECA stack? I used that in the past for cuts and it works great. It made me very indifferent about food, so following a specific diet was easy.
 
steven tyler aerosmith GIF
 
Gotta be honest. Yes, 63 isn't exactly young, but that is NOT what a healthy 63 year old looks like. She looks like she's in her mid 70s. I've seen people in their 80s that look healthier than that.
 
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Miyazaki's Slave said:
This week it was recommended to me not for weight loss...but for impulse control.

I did a double take and was told it was an impulse inhibitor and will help people who suffer from addition in many forms.
I have abused food my entire life as a coping mechanism, and while my weight is great (this year) the doc warned me about the inevitable backslide coming my way (thanks...also get fucked). They told me this would help lessen that or prevent it.

I have had a very rough year with docs (specifically the field of allergies) and this kinda of shit just drives me fucking insane. They cannot tell me if bananas or avocados are what turn my guts into a fire hose but they are SURE this will help lessen or prevent my addiction surges.

Also just for shits and giggles (and pettiness) I asked three ai agent tools; each one recommended against its use specifically for compulsion therapy.
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America? You hear things about how doctors are for pumping you full of drugs you don't need to be on, but this sounds bad. Not so much trained medicine man of science, more highly opinionated drug dealing. No wonder people think doctors are in the pockets of pharma companies
 
Brigandier said:
At the end of each month you can increase dosage by 2.5mg to a max of 15mg but you only need to increase if you really have to, I'm on 5mg now and increasing to 7.5mg next month and I expect that to work soundly and if so I can stay on that dosage if I'm happy.

But Drs and patients are just increasing each month "because fuck it"
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Eh, the "fuck it" from the doctors is kinda inevitable when the patient keeps saying "fuck it" to any other lifestyle intervention beside taking a pill or a weekly shot. And if we want to be blunt, "increasing the dose" is something the obese patient has been doing for quite a while, and they'll welcome it.

There's only so much a single doctor can do for someone. Pathological obesity needs teamwork and dedication, and let's face it: it's a rare one that gets morbidly obese and can muster the patience and willpower to solve their problem through teamwork and dedication. Those who have those, usually don't get to that point in the first place. If you don't have universal healthcare (which is rapidly collapsing everywhere in the face of chronic, wealth-related disease and redistribution of resources to certain specific segments of the population), it's even harder. Obesity is often a disease of the poor.

I've read that Mounjaro leads to a 10% loss in lean body mass. For someone that should already be very obese and not physically active, that sounds like a lot. You should need good exercise to contrast that as much as possible while taking the drug, and that's not easy for the typical patient. Sure, I guess celebrities can afford personal trainers and nutrition experts, but what about the average Joe?

Anyway, these drugs are only going to get more popular. Willpower and self constraint are just too hard for most people in this age. The only really good weight control plan is to never get fat in the first place, if your genetics don't push hard in the other direction. We'll see if Mounjaro and its ilk will actually decrease mortality in the typical patient, apart from QoL benefits and the reduced burden of disease weight loss should bring to the people taking these drugs.
 
I am now on my second Mounjaro pen, this thing is as close to a magic pill as anything can be. Cravings disappear, you actually prefer healthy foods, portion sizes and meal frequency corrects itself. Alcohol consumption is way down, I now opt for a half a pint as a full one seems too big - I had no trouble necking 4 pints before. I have excellent energy, sleep super well, and am generally happy. I really fucking love carrots now.

But I have done the ground work of building muscle for five years, doing resistance training 3-4 times every single week, plus swimming. You really need to work the muscle not to end up looking like a deflated balloon. That's where most of those horror pics come from, these people are not used to do sports.

My only side effect has been (really bad) heartburn twice when I had champagne to an empty stomach.

24/4 - 111.1kg (2.5mg)
1/5 - 109.1kg
8/5 - 108.1kg
14/6 - 107.9kg
19/5 - 108.0kg
22/5 - 107.0kg (5.0mg)
29/5 - 105.8kg
 
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rm082e said:
I've been wondering about this recently: Say you have someone who is really dangerously obese. Is it less risky to have them take one of these drugs, lose a ton of weight along with all the side effects like muscle and bone density, and then try to get them on an appropriate diet plan once the weight is off - or - try to get them to go on a diet and lose weight the natural way?
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You make the stomach bypass , but it requires an operation. I guess people are afraid or can't be bothered so they just yolo with the drugs.
 
Chittagong said:
I am now on my second Mounjaro pen, this thing is as close to a magic pill as anything can be. Cravings disappear, you actually prefer healthy foods, portion sizes and meal frequency corrects itself. Alcohol consumption is way down, I now opt for a half a pint as a full one seems too big - I had no trouble necking 4 pints before. I have excellent energy, sleep super well, and am generally happy. I really fucking love carrots now.

But I have done the ground work of building muscle for five years, doing resistance training 3-4 times every single week, plus swimming. You really need to work the muscle not to end up looking like a deflated balloon. That's where most of those horror pics come from, these people are not used to do sports.

My only side effect has been (really bad) heartburn twice when I had champagne to an empty stomach.

24/4 - 111.1kg (2.5mg)
1/5 - 109.1kg
8/5 - 108.1kg
14/6 - 107.9kg
19/5 - 108.0kg
22/5 - 107.0kg (5.0mg)
29/5 - 105.8kg
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So you are actively exercising - why did you need the drug again?
 
Cyberpunkd said:
So you are actively exercising - why did you need the drug again?
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I seem to have a very resilient weight set point around 110-115kg, I can use diet and cardio to push down to sub-100kg with extreme effort and focus, but it's not sustainable. I have done it three or four times.

I need to be at around 92kg to be at optimal weight for my muscle mass, so I am doing small doses of Mounjaro and it seems really easy and pleasant to get there.

I don't think I will ever go above 5.0, which is second lowest. My maintenance plan is 2.5 every second week for life. Reduced alcohol is a bonus, plus the cancer and cardiovascular benefits.
 
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Chittagong said:
I am now on my second Mounjaro pen, this thing is as close to a magic pill as anything can be. Cravings disappear, you actually prefer healthy foods, portion sizes and meal frequency corrects itself. Alcohol consumption is way down, I now opt for a half a pint as a full one seems too big - I had no trouble necking 4 pints before. I have excellent energy, sleep super well, and am generally happy. I really fucking love carrots now.

But I have done the ground work of building muscle for five years, doing resistance training 3-4 times every single week, plus swimming. You really need to work the muscle not to end up looking like a deflated balloon. That's where most of those horror pics come from, these people are not used to do sports.

My only side effect has been (really bad) heartburn twice when I had champagne to an empty stomach.

24/4 - 111.1kg (2.5mg)
1/5 - 109.1kg
8/5 - 108.1kg
14/6 - 107.9kg
19/5 - 108.0kg
22/5 - 107.0kg (5.0mg)
29/5 - 105.8kg
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If alcohol does that, you should probably avoid anything thick too, like peanut butter. It's more difficult to digest. Or spicy food. Good luck to you
 
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I don't know much about the drug's side effects but 90% of losing weight is reducing calorie consumption as opposed to working out. It takes a hell of a lot of activity just to burn a few hundred calories.
 
Mistake said:
If alcohol does that, you should probably avoid anything thick too, like peanut butter. It's more difficult to digest. Or spicy food. Good luck to you
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Yeah it was more stupidly on my part, hadn't eaten anything all day and then downed a lot of champagne.

If I have food it's no problem, I did a full champagne tasting evening with no issue but I had a prawn salad before and some bread sticks during the tasting.
 
jshackles said:
Short of any long-term side effects that we don't already know about, I'd say giving these drugs to people dangerously obese will almost 99% of the time lead to better long term health outcomes for those people. Worrying about things like muscle and bone density loss seem laughable in the face of obesity-related risks like heart disease and diabetes.

One thing to keep in mind - these drugs can take months to start working, and years to get someone to their target weight. Anyone who is properly taking these drugs under medical supervision will already have a long-term plan in place to mitigate these risks anyway.

What happened to poor Rosie here, something has gone wrong. Most likely, she's continued to take the medication after reaching a healthy weight, which can be quite dangerous.
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I'm currently taking Zepbound at the highest level of 15mg. I increased from 2.5mg to the max dose at the end of every box. I started seeing results 2 months in. I am getting close to my ideal weight 15 months in now.

The recommendation is once you reach your ideal weight, to bring it down to 10mg and only use it for maintenance one injection a month. But this will likely depend on what your PCP tells you to do.
 
I'm convinced that within 5-10 years, we're going to be seeing a lot of class action lawsuits related to these drugs and the long-term damage they will cause.

Aside from very specific cases, no one should be taking drugs to lose weight.

Weightloss is really simple: eat fewer calories than you burn daily.

Track your weight and daily calorie intake. Use that to figure out your TDEE (Total daily energy expenditure). From there, just figure out how much weight you want to lose a week and adjust your calorie intake accordingly. Eat 500 fewer calories per day than your TDEE and you'll lose about an average of 1 lb a week, which is a healthy amount to lose without losing muscle mass in the process.

If you live a sedentary lifestyle, start doing some light exercise.

At my heaviest, I weighed around 230. I'm now around 155. All I did to lose the weight was what I explained above and along the way I started lifting heavy to preserve and build muscle mass.

Was it always easy? No, but it was sure as hell a lot safer than injecting my body with Ozempic every single week.

EDIT: Word
 
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Chuck Berry said:
jesus christ dude :messenger_dizzy:

How can anyone say she looks good and healthy? She's fucking gaunt. Unrecognizable.



More and more people hopping on this lose-it-quick train and to me it just sounds like hell. Yes, you'll shed the pounds..in exchange for nausea and loss of muscle mass.
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I also think you got the wrong shot here




 
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muscle mass is correlated to lifespan so Ozempic making you lose not only fat but muscle as well could have significant side effects long term.

There are cases where it is preferable especially to extremely obese people but isn't advisable to do so just as a short cut.
 
Loss of muscle mass comes from not eating enough protein, not lifting weights, and/or losing too much weight too quickly, not the medication itself.

Plenty of bodybuilders using sema/tirz/reta to assist with a cut.
 
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You can try all the shortcuts, pills, and surgeries you want, but genuine health can't be faked. Humans have evolved an intuitive sense for identifying true health in others, precisely because selecting healthy individuals has always been essential for the survival and propagation of life. Genuine health radiates from the inside out and can't be manufactured through shortcuts alone.
 
I'm definitely not the fittest person, but I'm never taking any diet drugs. Past month and half, I've just been walking a bit more outside and doing some treadmill walking. Lost 12 lbs. And I just started doing light weights a few days ago (just doing some ultra basic bicep curls from watching a YT guy to see proper form). So I'll add in some basic weights a couple times a week.

I'm just trying to lose some wieght. Not be Mr Olympia.

I'm not even eating that much better either. Maybe a touch better, but still eating some chips and pop after dinner watching NBA and NHL playoffs.

It's actually not hard to lose weight. Just comes down to willpower, how much, how fast, and if your goal is simply weight loss or also trying to get some lean and mean muscle tone.

One thing that might work help avoid bad food in the fridge is stuff your fridge with more healthy stuff leaving you less room to put bad food in. It's tough since I'm single so I always got room in the fridge, but if I stuff it with more fruits, veggies, bottles of water, Brita water jug etc..... it crowds out the space to stuff it with 1kg tubs of macaroni salad (I love that shit!) etc... dont get me wrong, as I said I havent eaten much better but it's a start. I never planned to go cold turkey on tasty food or look like Schwarenegger. I just want to drop weight hoping I can get back to 20 years ago by year end. And if some light weights work helps tone up all the better. I just did the weights stuff more to do from walking boredom, so it's something different to do.
 
StreetsofBeige said:
I'm definitely not the fittest person, but I'm never taking any diet drugs. Past month and half, I've just been walking a bit more outside and doing some treadmill walking. Lost 12 lbs. And I just started doing light weights a few days ago (just doing some ultra basic bicep curls from watching a YT guy to see proper form). So I'll add in some basic weights a couple times a week.

I'm just trying to lose some wieght. Not be Mr Olympia.

I'm not even eating that much better either. Maybe a touch better, but still eating some chips and pop after dinner watching NBA and NHL playoffs.

It's actually not hard to lose weight. Just comes down to willpower, how much, how fast, and if your goal is simply weight loss or also trying to get some lean and mean muscle tone.

One thing that might work help avoid bad food in the fridge is stuff your fridge with more healthy stuff leaving you less room to put bad food in. It's tough since I'm single so I always got room in the fridge, but if I stuff it with more fruits, veggies, bottles of water, Brita water jug etc..... it crowds out the space to stuff it with 1kg tubs of macaroni salad (I love that shit!) etc... dont get me wrong, as I said I havent eaten much better but it's a start. I never planned to go cold turkey on tasty food or look like Schwarenegger. I just want to drop weight hoping I can get back to 20 years ago by year end. And if some light weights work helps tone up all the better. I just did the weights stuff more to do from walking boredom, so it's something different to do.
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You sound like me. And christ I love fucking macaroni salad.
 
Chuck Berry said:
You sound like me. And christ I love fucking macaroni salad.
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I ate some for breakfast!

One tip for losing weight for any of you who have never worked out is stick with it for a couple weeks. Just do basic shit like me walking on a treadmill at random incline setting. And pump up the speed rating to something decent (the default zero setting is like crawling speed).

It's funny because I'm overweight and every fit buddy whose given me tips in the past says it should be easy to drop pounds fast because I got a lot more to lose then they do.

Absolute BS.

There's been a few other times I tried working out over the past 20 years and never stuck to it due to being lazy AND most importantly the first bunch of days of working out I lost nothing. Not even one pound. So I'd lost motivation and quit.

This time I stuck with it and the pounds did start coming off soon after. It started reflecting around a week later for me.
 
DGrayson said:
Loss of muscle mass comes from not eating enough protein, not lifting weights, and/or losing too much weight too quickly, not the medication itself.

Plenty of bodybuilders using sema/tirz/reta to assist with a cut.
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I'd argue that the loss of muscle mass is coming from the medication, since the loss of muscle mass is related to weight loss, which the medication is causing.

One of the dangers of these meds is that doctors seem to be prescribing them like candy and not requiring that patients also see a dietitian and engage in physical activity to ensure that their diet and weight loss is healthy. Not to mention ensuring that they make lifestyle changes for when they eventually go off the meds. Although I'm sure the drug companies would love to create some lifetime weight loss customers...

It just reminds me of how doctors were treating opioids when they were introduced, and I'm sure, just like opioids, there's some sleezy pharma rep trying to get doctors to prescribe Ozempic to as many people as possible.
 
Poppinfresh said:
It just reminds me of how doctors were treating opioids when they were introduced, and I'm sure, just like opioids, there's some sleezy pharma rep trying to get doctors to prescribe Ozempic to as many people as possible.
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It's supposed to be illegal I think, but surely still happens.

Incentive payouts.

My good buddy's dad used to be a pharmacist (retired). He'd get pharma company payouts from the rep if he stocked lots of the company's products. The rep would literally go into the shelves and just eyeball what's on the shelves. If it looks like he carried lots of the company's drugs he got an incentive pay out. Pretty shady way to push drugs and also a shady way of even evaluating it.

I even asked him can his dad just fake it with empty bottles, but I guess that's too shady as he said his dad didnt go that far. lol

Consumer goods used to be full of this shit too long time ago. The old sales vets who've been around since the 80s would say it was the wild west back then. If a store manager agreed to order a skids of product, the rep would send him fishing rods, or a small TV etc.... If a store is franchised then go ahead. Do what you want. But back then, youd get corporately run stores where the store manager is fucking around getting free shit buying up stuff the store doesnt even need. And it was so sketchy, the store manager would ask the sales guy to drop it off at his house. They'd tell me when they'd visit his house to deliver it, the store manager's garage would be stocked with perks and freebies. But the industry cracked down on that stuff in the 90s and early 2000s. And the best way to do that is to not allow managers at corporate stores to order anything. All inventory orders are handled by someone at head office or automated orders based off sales data.

A lot of shady shit when it comes to stores.
 
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Poppinfresh said:
One of the dangers of these meds is that doctors seem to be prescribing them like candy and not requiring that patients also see a dietitian and engage in physical activity to ensure that their diet and weight loss is healthy. Not to mention ensuring that they make lifestyle changes for when they eventually go off the meds. Although I'm sure the drug companies would love to create some lifetime weight loss customers...
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The indication for Mounjaro specifically says: "Mounjaro (tirzepatide), an injectable prescription medicine, is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus."
On a surface level, I'd expect that patients are at least instructed about dieting and exercising. Whether they actually do it, and whether their doctors can actually do anything to push them to, is of course another matter.
The point is, no, you're not supposed to go to a doctor because you're morbidly obese and/or diabetic and the doctor just says, "OK, just inject this once a week and keep eating all kinds of shit and sitting on your ass all day. Now off you go, champ!".

Again, in countries where there's universal healthcare, these criteria are supposedly more restrictive and doctors have to follow them. What happens in the land of the free may vary wildly, but I don't know about that.

This is not to say that pharma doesn't really like a world where you're on as many of their products as possible, or that doctors aren't *wink wink* strongly encouraged to overprescribe some stuff.
 
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