Nah it's rather easy. Any 'twitch' reactions aren't really that hard and you get used to their patterns rather quick. In your case MAYBE the part you might have trouble with is jumping on enemies since against some enemies being a little in front or behind them when you land might hurt Mickey.
Don't let it turn you off though, if you got a strong PC/Laptop fire it up and let your jaw drop at how beautiful the visuals are.
Thanks for the info! You got me curious about the nice visuals but I won't search for gameplay of it since I want some good surprises when I get to play it.