Ugh, I quicksaved in Fallout 4 just as a projectile was flying towards me, so I die the instant I reload... damn it sucks to go to an old save.T_T
Really, if you exclusively use quicksave then you're just asking for that to happen lol.
I usually use at least three different hardsaves if possible that i use in successive order, i.e. Save 1 --> 2 --> 3 -->1 --> 2 --> 3 in case one of them gets corrupted or something.
Two very traumatic save experiences i had where the following two:
One time i was playing Crash Bandicoot 3 on my PSX when i was saving and suddenly a message popped up recommending me to reformat my Memory Card. I didn't really paid attention so i just hit yes.
All my saves where gone. The Crash Bandicoot Trilogy that i nearly 100%ed. My Spyro saves. EVERYTHING.
I don't remember precisely, but i think i cried.
The other time i was playing The Hobbit on PS2. I was stuck at a point where i had to fight a spider, but wasn't able to do it because i didn't understood how to use a certain mechanic or something. So i started a new game in order to revisit the tutorial area and learn that. Then i came across a savepoint in th tutorial and started saving, cos that's what you do at savepoints, right? Yea right. I never touched that game again, afterwards. I don't think it was a good game anyways.