I just read a preview where they say that some of the choices will be time constrained... I'm sure that those choices will not be easy ones. Wholly damn, that is going to make me sweat buckets - I always like to carefully consider my choices in games like this to make sure I'm making the choice that I want.
Most of the time, it hasn't been a challenge to make the choice that I know I want to make - the hardest / most annoying was the fight between Jack and Miranda in Mass Effect 2 because I was definitely going to choose Miranda - I just don't like that you CANNOT save the other without having almost perfect Paragon / Renegade points. I hope the choices aren't like that in Witcher 2, however I suppose there will be big differences depending on the choices - but as long as they aren't clear cut and require thought and consideration (which I'm sure they will) then they won't annoy me but rather will compel me to play more and want to see the outcome of such choices.
But, if I have the choice of killing someone or not like the Witch in the first game - I have trouble sentencing anyone to death, especially a character like that, but if there is a choice of choose if this person or that person... that's the type of decision I will have trouble with (unless I really and clearly dislike a character).