This is a quote from Wells in a Polygon interview, and if you search online, their statements were all about the franchise, not Drake.
I would say that Naughty Dog doing an Uncharted after this is unlikely, studio co-president Evan Wells told Game Informer. I would never say never, but we've got The Last of Us Part 2 on our plates and there's so much other stuff that [we want to explore].
I mean, their goal was to "end" Drake' adventures with UC4, but their desire to move on was from the franchise overall.
Here are a couple of links you can check:
https://www.google.com.pr/amp/s/www...rted-lost-legacy-franchise-future-naughty-dog
https://www.google.com.pr/amp/s/gamerant.com/uncharted-4-last-game-359/amp/
https://www.google.com.pr/amp/www.t...t-in-its-series-because-it-s-hard-to-make.htm
They already backtracked from that anyway and will probably come back for more, just not with Drake I would imagine.