My cousin beat Quakshot first time!!!! It took me months to beat that game, and he just blew right through it (although I owned all at Sonic 3, and even managed to best him at Street Fighter II after awhile).
Looking back that was a pretty easy game though (Quackshot), It's part of my regular PSP rotation now, and I can pretty much blow through it in slightly over an hour and a half. Half the battle was just figuring out what I did next when I was a little kid (it was one of my first Genesis games after Madden, LHX, and Sonic 2)
Lotsa good memories associated with all those games (used to play Ducktales on NES at my bros' freinds house all the time, one of my favorite NES platformers ever.)