OK, here's my wish list:
1. Collection of Activision's Commodore 64 games. They did one years ago called Commodore 64 15 Pack, shortly after Windows 95 came out. It was one of the first pieces of entertainment software made specifically for Windows 95. It was pretty impressive for its time, but the sound emulation was rather shoddy (too bad, because C64 had a wicked sound chip), and it doesn't work very well under Windows XP.
2. Collection of Epyx's Commodore 64 games. Everyone should experience the true wonders of 8-bit gaming that are Jumpman and Jumpman Junior, and of course Impossible Mission! (I've never played Impossible Mission II, so this would be a good opportunity for me to catch up!) Throw in the "Games" series (Summer Games, Winter Games, California Games to name the most popular examples), the Apshai series, Pitstop, Pitstop II, Super Cycle, and maybe a few others, and you just might have one of the best compilations ever. And I do mean ever.
3. Castlevania collection. Like others have said in this thread, I'd like to see it include Dracula X, because I've never played it, and this would probably be my only real chance at ever sitting down wth it.
4. Lemmings collection.
5. Collection of Atari Lynx games. I'd include most of the early Epyx-developed games such as California Games, Blue Lightning, Electrocop, Gates of Zendocon, Chip's Challenge, Todd's Adventures in Slime World, and Zarlor Mercenary. You could also add some of Atari's in-house originals like Warbirds, Checkered Flag, and maybe a couple of other third-party developed (but Atari-published) puzzle games like Crystal Mines II and Super Skweek. I doubt I'll ever really see this, but if there's any justice in the world, Atari should consider making this happen for newer handhelds like the Sony PSP, Nintendo DS, or Tapwave Zodiac.