Kraven's Last Hunt doesn't really sound like "first Spidey movie villain."
(If they wanted to do KLH, they should cast Kraven and have him appear as a side character for a movie or two and then do KLH.)
Yeah, this. You have to build up a relationship between Spider-Man and Kraven for KLH to make any sense at all. Either that or you would have to vastly change Kraven's character to make it fit as the first plot with him in. Audiences would think he was a super-intense character if that was their first exposure.