The biggest missed opportunity is the inability to ever add more games to this thing.
I mean, pre-orders here in Aus are sold out. I pre-ordered just a few hours after they were available, and I'm stuck on the second shipment. This is gonna sell gangbusters.
Companies like Capcom, Konami etc are gonna want to jump on board and get a piece of the action. Can you imagine paying an extra $10-15 and getting another 20 games? This is money left on the table by Nintendo, and is so typical of them.
Just put a damn WiFi card in it, and quick subset of the eShop, and you're golden.