Everytime I see the WiiU controller I think it will cramp your hands/wrists after a while. You have to hold your hands pretty far apart, isn't that an ergonomic nightmare?
No--putting the hands as close together as typical dual analog controllers do is a utilitarian compromise, not an ergonomic feature. Check your posture when you hold one, it tends to make me tuck in my elbows and bend my wrists ever so slightly more than is comfortable.