ThatObviousUser
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The end of Pokemon B/W did set up for a sequel...Isn't N seen flying off to a new region with his Zekrom/Reshiram?
He's seen flying off somewhere. I think Looker implied he was off in another region, though. Everyone sort of assumed it wasn't one of the five already known, but thinking about it BW2 can do anything. They can take place anywhere and include any and every character in the entire series up to this point, and then some.
Game Freak not being tied down to focusing on a new region, set of Pokemon, and team this time around could prove incredibly liberating when it comes to taking risks with the single player campaign and story.