My Inferno build is kind of... unorthodox, I think. Though I suppose the game is new enough that there's not much orthodoxy for me to deviate from.
It's basically a totally tanking- and kiting-oriented build that has no mana regen to speak of and so basically doesn't spend any. Poison Dart with Splinters is the main single-target DPS, Firebomb with Flash Fire is the AOE attack and is also used because it can hit things that are off-screen, Spirit Walk is my general healing/kiting/traversing/fleeing skill and is used because it is the best Witch Doctor skill I mean
seriously, Soul Harvest is there for the DPS boost but also because of inertia, Gargantuan is my main tank and the AOE stun comes in handy far more often than I expected, and Zombie Dogs are theoretically there for the 10% across the board damage reduction but are actually there because
I am taking those dogs to the end of Inferno no matter how useless they are and there is nothing the game can do to stop me.
The passives are all totally survival-oriented. Jungle Fortitude is obvious, Zombie Handler increases the amount of time my pets can pull aggro, and Spirit Vessel is a Get Out of Death Free card on a 90-second cooldown that also lowers the cooldown of my most important survival skill.
I exclusively play solo and have the Enchantress tag along for bonus DPS and for the 15% armor increase. Templar's heals have the same problem the Witch Doctor's integer-based heals do and become useless and I've got plenty of things to draw aggro already, and the Scoundrel doesn't do anything to boost my survivability. I also think that in most situations the Enchantress actually out-damages him thanks to her surprisingly effective AOE attacks.
It's basically the build I cleared Hell with, and it's held up in Inferno better than I expected it to, frankly. I can actually handle most unique enemies that don't have Waller, though depending on the skill loadout it can take forever and a day to whittle them down so I end up skipping quite a few of them purely in the interest of time.