Oddly, only two weapons and two vigors can be hotkeyed at any given time (via a quick tap of the Xboxs shoulder buttons or the PS3s triggers). The rest of your arsenal is accessible, of course, but you must pause and go into a menu in order to get to them. That can break up the fun flow of an otherwise high-octane encounter, and picking the right tool for the job during the fight was something I found myself avoiding. As you might expect, though, these are non-issues on the PC, where the number keys offer instant access to vigors and the mouse scroll wheel zips through your full list of guns.
So is there or isn't there a two-weapon limit?