Surprisingly, no, given that I've been frequenting bars since my early 20's and still do so regularly. I'm no troublemaker, but over the years, I've gotten in the face of a few people who were starting shit with my friends, and had some choice words/put my hands on a couple of them. Nothing ever went beyond that, fortunately. I'm hardly a tough guy, but I'm not small, so I guess that works in my favor.
I find that most people are trying to avoid fighting, drunk or not, and the ones that are interested are pretty easy to spot so they can be avoided or dealt with in a less aggressive manner.