RE: The Handyman discussion from a few pages back -
Use movement to fuck up the Handyman, getting on rails to have him chasing you and off when he's about to shock it. That'll open up opportunities to shoot at his heart and get him in position to lay traps, using Undertow to pull him into traps if need be (best used with Shock Jockey for a stun).
Generally shoot him in the heart when available, particularly when he's stunned or distracted. He'll occasionally do stuff like cough which gives you an opening, or you can distract him with Murder of Crows. Vary your tactics appropriately based on what sort of stuff you've been upgrading and gearing up with, but good movement is generally the key against those guys. If you're largely sitting there trying to have a battle of attrition with him, it won't bode well.
I find those fights super-fun in 1999 mode. I've seen a lot of people liken them to Big Daddies but I think that comparison is wrong; they're more like a Big Sister, except the fights are far more movement-based on your end. The Big Daddies were memorable because of their melancholic and bizarrely affectionate demeanor in contrast to their appearance, but I never found them particularly interesting to fight, even in Bioshock 2.
This game's combat reminds me of Bulletstorm to an extent. Both are shooters which are extremely rewarding of player creativity, along with having hectic and movement-heavy combat.