Nephilim + Hardcore + Turbo.
Said it before and I'll say it again, it's how you should roll even as a DMC non-veteran.
You have to remember the game has many healing items, revival after death items, and a very lenient checkpoint system that gives you a checkpoint for every new encounter.
This is me playing on those settings Dahbomb and I recommended.
And I'm playing with a cast on my thumb. What you see is something that is fun, not hard. If you see that video and you think to yourself, fuck that. Than maybe choose Devil Hunter. But turbo mode hardcore mode is a must. Hardcore mode also sounds more scarier than it is. They should have just called it "properly balanced mode." Also, it's actually more easier when you play it at 60 fps, PS4 upload to youtube only does 30 fps so the youtube video looks harder than it really is due to the lack of fluidity.