The number of New Vegas mods is... intimidating. I'm about to do my first NW playthrough. What are the must-have mods or should I play straight up?
So far, I have downloaded Nevada Skies... but not sure about rest...
Generally, I would recommend that you avoid heavily modding any games the first time around. I would just stick with Yukichigai Unofficial Patch - YUP.
However, if you really want to go all out with modding just follow the link ZzzZombi posted:
The guides over at STEP cover pretty much everything you'd need in terms of mods and tweaks. They're also fairly up-to-date. For Fallout 3 and for Fallout New Vegas.
For the most part, you can just pick and choose which mods you want. The mods listed in the guide are all pretty good.
Dick Justice posted this earlier:
I'd really recommend not using Mission Mojave, it makes a lot of unnecessary changes, and Yukichigai's patch does a much better job of fixing bugs, with far less bloat.
I'd also recommend using Realistic Wasteland Lighting instead of Nevada Skies, less weather patterns but it looks a lot better IMO.
Install Anti Crash and Stutter Remover too.
For visuals, take a look at this list (don't bother with Hall of Equipment, the mod author just doubled the size of vanilla textures and threw some filters on, so they look shitty).
For top priority, I'd say install Poco Bueno, and place it below NMC in your mod list. Interior Lighting Overhaul does a great job with interior lights.