Aliens: Colonial Marines debuted at number one on the UK all formats chart despite the negative reception, similar to the 2010 game Aliens vs. Predator.[72] According to GfK Chart-Track it was the biggest release of the year in the UK ahead of Dead Space 3, and held the second highest first week sales for an Alien game since Aliens vs. Predator.[73][74] The game was number one on both the respective Xbox 360 and PS3 individual charts.[75]
In the U.S. the game debuted at number six on the all formats chart in its first month of release.[76] As of May 10, 2013, as stated in Sega's end-of-fiscal-year report, Aliens: Colonial Marines has sold 1.31 million units in the US and Europe.[77]