People have already brought up Wasteland 3 (this one is legit fucking hilarious and has X-com style gameplay) and Yakuza: Like A Dragon (playing through this now, and it's great).
Also, the South Park games. I've only played Stick of Truth, but it was one of the funniest games I've ever played. I've heard Fractured but Whole has better combat, but is a slight step down in the comedy department.