Pretty much up for any of the directing choices. They're all solid directors. It's the writers they should be more worried about.
While they've been hit and miss so far (I'm with the camp that says Skyfall is a good film), its worth noting that both Quantum of Solace and Spectre didn't exactly have the smoothest production cycles. If Bond 25 can be made without issues, they should be able to turn in another solid script.
Birth.Movies.Death dropped a rumor in their recent Bond update that suggests EON is strongly considering selling itself to a studio once this one is done.
Warners might be (if this is playing out correctly) putting itself in a position to buy Bond outright.
Which is probably why all the Nolan speculation has been all hot & heavy the last week.
Variety seems to think WB is closest to landing the distribution deal
If WB gets it, then a Nolan Bond has got to be in the cards. November 2022, 60th anniversary. It lines up too well.
Gonna add to this bit and note that if Warner Bros. gets the Bond distribution rights and then EON Productions themselves, that would give them carte blanche to acquire MGM.
MGM (through United Artists) co-owns the the copyrights/trademarks of Bond as well as the video distribution rights to the films, which is undeniably MGM's most valuable asset. Warner Bros. also holds the rights MGM's pre-1986 film library and has been co-producing and distributing a hefty amount of MGM's recent films (such as The Hobbit trilogy, Creed, and the upcoming Tomb Raider film).
Getting MGM also allows Warner Bros. access to the film/television library of other studios MGM's acquired over the years, such as the aforementioned United Artists, Orion Pictures, Polygram, and the pre-1994 Castle Rock Entertainment library (that studio of which has been a longtime Warner Bros. subsidiary).