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NeoGAFs Kent Brockman

Is Commander Shepard in Mass Effect 5? Voice Actors Comment on Return
Is Commander Shepard returning in Mass Effect 5, the tentative name for the new Mass Effect game that was revealed last December at The Game Awards? This is the million-dollar question on the mind of every fan of the sci-fi RPG series after the one and only teaser trailer seemingly hinted at the...

For Commander Shepard to return, BioWare and EA would need to get Jennifer Hale and Mark Meer -- the voices behind the female and male version of the character, respectively -- on board. Those hoping to see the character return will be excited to hear both actors are on board.
"I'd jump to come back and do anything in the universe, especially, obviously more Shepard," said Hale, in response to whether she would be interested in returning to Mass Effect, before passing the metaphorical mic to Meer to respond. Jumping in, Meer says, "We talked about this with the previous interviewer, the Mass Effect universe is so fully realized, and so well thought out, and it feels like a living place. I just want to see more stories in that universe. And I'm speaking strictly as a fan, not as a voice actor who's hoping to get work, but as a fan of the franchise, a fan of the universe. I want to see more stories from all corners, from various points in the established history, stuff that's only been referenced."
Meer continued:
"I'm going to throw a random example out, I have no inside knowledge, but I'd love to see stuff set during the First Contact War, I'd love to go even further into the future. I could almost see a game that's set where you're playing the Protheans and they're reaping, like the historical setting. There are so many possibilities, it's almost infinite. And then also given all the multiverse that's flying around in pop culture these days, I want to see Mass Effect What If?"