The Sayles script we actually saw didn't actually go that far with hybridization--the Indominus was actually another level above anything in the script that leaked, at least how they were described (well, except the "Excavaraptors," don't know what was up with those). The insanity of the Sayles script came mostly from the events and scenes in it. I know we've seen those weird Isle of Dr. Moreau level strange concepts but I don't imagine the series ever going in that direction. But then again I would be cool with never seeing something on the level of the Indominus (or JW's attempts at
actual animals for that matter) in this series ever again, but I have a feeling they will only want to go in the direction of sequel escalation.
I'm kind of sick of them attempting to "one-up" the Tyrannosaurus as the main dinosaur villain. In TLW it was two Tyrannosaurus. JPIII it was the Spinosaurus. JW has the Indominus. And every single one of them forgot that the Tyrannosaurus was not the main dinosaur villain of Jurassic Park. The raptors were. Oh the T.rex had the main show stopper scene, but it didn't drive the movie's plot.
EDIT: I'd actually like to see them drop the T.rex and raptors entirely for one film and introduce some new animals to terrorize people (and not just straight replacements like the Spinosaurus and Indominus were), but I know that isn't even remotely realistic.