Inventory problems?
Well, the inventory limit is not unreasonable. Only once have I ever come close, after completing 4 side quest planets with many dungeon areas - it's generally a good idea to pop back to the Citadel and check the vendors anyway at that point.
The way the gear is only organized on the "Sell" menu in terms of increasing cost and the slow, slow scrolling is the real problem in my eyes. It would be nice if they had a "skip down" button or the scrolling would accelerate.
Frame rate problems? Never had any, but then I've never been a big frame rate whore so I might not be the best one to notice that sort of thing. I mean, I've run into a "Loading" mid combat once, but that was a brief pause and then we were back in business.
Texture pop? Yeah, it's pretty bad, but you get used to it.
Film grain and motion blur? I like 'em, but hey, easily removable if you don't.
Done every side quest available again, and I was right, completing new story planets not only moves the romance tracks forward, they unlock like 4-5 new star systems and ~3 new quests. So yeah, nothing left to do on my map right now besides Vermire and Noveria. Noveria first, definately.
I'm fairly happy with this game. The story planets so far have had a lot of content and much of it quite good. The side quest planets have highly repetitive terrain with mildly changing scenarios and encounters, so they can get kind of tiresome, yeah. This is nothing new for Bioware, though - as I said, the planet exploration maps remind of individual screens for exploration back in Baldur's Gate. Perhaps in ME2, as in BG2, they will eschew this method and move to larger, more interesting side areas and side quests.