No way in hell Wii U reaches 100k based on a game like Monster Hunter. Like predicting Gravity Rush to sell a ton of Vitas. Niche franchises do not push many systems. You would have an easer time if you said Lego City, but even then I don't think parents will be buying their kids a 300 dollar console to play the newest lego game. I don't understand why anyone thinks Lego City is actually going to drive sales. We've seen so many Lego games over the years it's not even funny. No matter how different this one is it does not change that fact. The game will also have a version (even if its not the same) on 3DS. No the first game that has a shot at pushing a significant number of Wii U's is Pikmin 3.
You'd have to clarify 'significant number' because I don't see Pikmin (a sequel to Gamecube games) as something that incites a more than marginal amount of consumers outside of early adopters to buy the hardware.