I think there is a big difference from QB to QB and from team to team to the point where it does affect play styles. For example, I was playing a game last night with Rors and I had coles over the middle about 8 yards deep and I threw the ball to him. I did nothing different than I have ever done with Eli or whoever I use, but the ball floated so far ahead and for so long that Schweigert was able to jump it. That int would never happen with any other QB, I am convinced of that. Even Rors said it, the ball hung up there for what seemed like days.
On the other hand, I was playing in the rookie's league with Brett Favre and the Packers and I was destroying dudes through the air.
I think the bottom line is that when you pick a team you have to be committed to play like them in real life, they always play to their strength. That of course, is why I suck with the Jets. :lol