I agree with everyone calling for a full hour to make this work. Keep it 100 is obviously the highlight of the show. You could do a half hour of just that. Asking tough/funny/tough+funny questions of interesting people and then calling them out if their answers are insincere makes for good TV. The discourse in our country has become so marketing driven - every press conference, presidential debate, congressional hearing - you name it - is the same heavily managed, rehearsed, buzzwordy marketing package. There's a huge disincentive to actually say anything meaningful or sincere. It's nice to have a format that calls that out. You look better stating an unpopular opinion than waffling and trying to get out of it.
They get some genuinely interesting people on the panel each night. But man, they just do not have enough time to have a meaningful conversation about anything. Larry does a good job making sure everyone gets to say something, but at the expense of actually having a discussion. You basically get one question per panelist and it's often wasted in service of getting a laugh. I want the laugh, but if the segment had more time to breathe, you could get a little more back and forth and maybe have a few more of the interesting moments that they currently reserve for keep it 100.
I guess I was hoping for something a bit more like John Oliver has done with his show. To differentiate it from The Daily Show, Oliver does those great longer form pieces. You hear a lot more about each topic, which also gives Oliver the chance to tell jokes that require more of that background. It really works for me. I remember a quote from Bill Waterson about how things are always funnier when they're more specific. The joke you can make in a 30 second bit on the Miss America pageant is very different than the one you can make if you've built up 10 minutes of background.
I want to see the Nightly Show use the panel format to really mine those deeper veins of comedy and commentary. The potential is absolutely there. Give the panel another 20 minutes and I think you'll have a show that we're all talking about the next day.