Some thoughts as I started the game: get to Megaton, get directions to Rivet Town: in Rivet Town there's an Int bobblehead. Int bonuses are better the earlier you get them. It's kind of hard to get there, but if you're careful you can make it.
There's a big ol road that crosses the river to the northeast of Megaton, and over there is a raider ruin where there's a ton of skill books and a Lockpick bobblehead. If you don't have 50 lockpick, this'll help you get into the Sheriff's house so you can get the Strength bobblehead.
Getting a perk every single level I found surprising. I wasn't expecting it, and didn't plan for it. That's what I get for trying to min-max a game I'd never played before. :lol
Also, if you don't already have a 10 int (and if you have a 9, go to Rivet first), boosting your Int stat is better than any +5 / +5 skill, for obvious reasons. Boosting Int at L2 will give you 18 skill points over the course of the game. The 2nd level perks mainly suck. +5 / +5 Perks, XP bonus (never been useful in any FO, as xp has always been plentiful), and Lady Killer, well, I guess that's some interesting flavor, but nah. So early on boost stats, definately. Had I known Perk every level, I would have tried instead to get max strength without power armor (I love power armor, but unlike in FO and FO2, there's some alternatives that are almost as good, without the penalties, and indeed, the penalties are higher in FO3, since power armor never reduced agility before, just gave a sneak penalty - in at FO:T, at least).
At L4 Comprehension and Educated appear and those are very attractive prospects, obviously (Educated is like 3 points of Int, and you take it if you already have 10). Iron Fist sounds kind of cool, but Unarmed only.
Can't wait for Toughness at L6 for this guy. Still seems like a lot of levels open for stat boosting for this guy. After L11, boosting Int is worse than picking up a +5/+5, but at that point there should be some better options (Strong Back, Commando, etc).
After that, I'm thinking Silent Running, Lifegiver, Pyromaniac, Cyborg, Better Criticals and Action Boy. L18 stuff sucks for me, I think. L20 has Ninja.
I was initially surprised skills stopped at 100 and tag skills didn't do double points. You really couldn't "max out" everything in FO & FO2, but it sure looks like you can here.
There's a big ol road that crosses the river to the northeast of Megaton, and over there is a raider ruin where there's a ton of skill books and a Lockpick bobblehead. If you don't have 50 lockpick, this'll help you get into the Sheriff's house so you can get the Strength bobblehead.
Getting a perk every single level I found surprising. I wasn't expecting it, and didn't plan for it. That's what I get for trying to min-max a game I'd never played before. :lol
Also, if you don't already have a 10 int (and if you have a 9, go to Rivet first), boosting your Int stat is better than any +5 / +5 skill, for obvious reasons. Boosting Int at L2 will give you 18 skill points over the course of the game. The 2nd level perks mainly suck. +5 / +5 Perks, XP bonus (never been useful in any FO, as xp has always been plentiful), and Lady Killer, well, I guess that's some interesting flavor, but nah. So early on boost stats, definately. Had I known Perk every level, I would have tried instead to get max strength without power armor (I love power armor, but unlike in FO and FO2, there's some alternatives that are almost as good, without the penalties, and indeed, the penalties are higher in FO3, since power armor never reduced agility before, just gave a sneak penalty - in at FO:T, at least).
At L4 Comprehension and Educated appear and those are very attractive prospects, obviously (Educated is like 3 points of Int, and you take it if you already have 10). Iron Fist sounds kind of cool, but Unarmed only.

After that, I'm thinking Silent Running, Lifegiver, Pyromaniac, Cyborg, Better Criticals and Action Boy. L18 stuff sucks for me, I think. L20 has Ninja.
I was initially surprised skills stopped at 100 and tag skills didn't do double points. You really couldn't "max out" everything in FO & FO2, but it sure looks like you can here.