Pretty much everything involving Twitch chat. It's fine in its natural habitat, where you can ignore it or just tune it out. It all moves so fast anyway that it basically just turns into noise. But when it crops up elsewhere.....ugh.
Jojo's Bizarre Adventure, I guess, though I'm a giant hypocrite and legitimately love the "To be Continued..." meme. But people push that shit way too hard; it's a great series but I don't really like the super internet-y, meme addled fanbase it's gotten in the last few years. Maybe that makes me a hipster, IDK, but it's lost something.
The whole Member Berry thing from South Park. Not agreeing with nostalgically inclined arguements is all well and good but I can't stand when anyone uses a meme to make their arguement for them rather than actual critical thinking. And it's becoming distressingly common. South Park is pretty bad about these sorts of things, the whole Turd vs. Douche thing was equally bad.