uncharted card game in the vein of magic the gathering is sure such a weird combination. I played a few card game before and other than the strategies and satisfaction of pulling off a strategy from a customized deck, my enjoyment largely comes from enjoying the fantasy artwork, various monster/artifact/magic ability design and description the game world has. Uncharted on the other hand seems pretty bland in that category since even though it has some magic and supernatural element to it, it's mostly pretty grounded in reality.
you know what card game would fit Uncharted better? make a poker game where various uncharted character just play poker and chat in a table, make a twist to the formula like each character have different ability to cheat or something, give it good presentation and animation of character reaction, bluff, etc, give it some nice and funny dialog and I'd buy that. who wouldn't want to play a poker game with Drake, Eddy, Sully, and Chloe and they just talk with each other when playing it, talk about their past adventure.