I think they're going to be a lot more predictable.
Spider-Man: Far From Home - Post Avengers, everyone misses Tony Stark, Spider Man's refusal of the call bundled with him meeting up with Nick Fury / Shield and will kinda be for Spider Man what Winter Soldier was for Captain America. Mysterio will claim to be a good guy, but will end up being a bad guy. Peter Parker's friends will obviously be involved and might even be "let in" on Spider Man's identity.
Black Panther 2 - Another black panther side-movie, because $$$. Might focus on how the world now knows that Wakanda exists due to the battle with Thanos being there, and will tie in with the first Black Panther movie where Tchala wanted to expand the country's cultural outreach. The bad guy will probably be someone who seems like they're trying to help at first, but will actually be trying to take over Wakanda's export economy or something. Will have a really heavy-handed message, but ticket sales will be gangbusters.
Doctor Strange 2 - Another one-off film where the stakes are relatively low but we'll discover what the extent of Doctor Strange's power is when he's stripped of the time stone. Awesome trippy visual effects like the first one. Probably paired with Captain Marvel to help shoehorn in more of her story arc. Will end with Nick Fury showing up to officially recruit Strange.
Asguardians of the Galaxy - Basically the combination of Thor: Ragnarok with Guardians of the Galaxy. Korg will be tagging along with Thor, Star Lord, Drax, Mantis, Rocket, and Groot. The soundtrack will be "old rock" like more Led Zeppelin and Boston, all played from Star Lord's new Zune MP3 player. They'll get wind that Gamora is alive (or at least they'll think it's her) but it turns out to be another of her race, maybe a sister (still played by Zoe Saldana). Thor will do something epic like establish a new Asguard or somehow bring the old one back.
Captain Falcon America - Sam takes on the mantle of Captain America, while him and Bucky work closely with Shield (continuation of the arc from Spider Man) to take on some sort of freedom-hating fictional third world dictator. Even though Falcon doesn't have any super-powers, he'll discover that taking on the name of Captain America is more about winning the hearts and minds of the people than having super human strength.
Iron Woman - Pepper Potts, along with Shield and Stark Industries, basically continues Iron Man's legacy. It'll be a cross between an origin film and established universe lore. Some worldwide threat will show up and it'll be up to Pepper to save the day. Lots of flashbacks to Tony starring Robert Downy Jr both young and old.
These movies will almost all entirely gloss over the gaping plot holes that Endgame created - they might talk about "the snap" or surviving for 5 years, but won't ever answer questions like "what about couples where one member went missing and then show up 5 years later without aging?". The absence of the infinity stones will mostly be glossed over or not talked about at all. Time travel probably won't be a huge element, even though now we know it's possible and will constantly be asking ourselves "why don't they just go back in time to change X?".